The memes starts with questioning the knowledge of God. We know that God is all knowing (Psalm 139:4, Job 24:31, 1 Samuel 23:10-13, Genesis 20:1-7 and many others). Therefore, yes, He was and is well aware of the sin to come.
From there is the assumption that God is not just because He knew that we would rebel and punishes us anyway. But, we know that God is a just judge (Hebrews 4:13, 1 Samuel 2:3, Job 34:22-23, Ecclesiastes 12:14 and many others). I’ll throw in that God does not judge by what we don’t know. He judges but what has been made plain to all of us already. It’s really important to remember this one (Romans 1:18-19).
It does get one thing right. In God’s righteous judgement, the punishment for sin is indeed death (Psalm 145:10, Matthew 25:46, Galatians 6:7 and many others). And that’s where the message ends. It completely omits the gospel.
From those verses, we know that God is both all knowing and the just judge. If God is just, He has to punish evil. We all sin, so in all fairness, the just judgement against us is death. Yet, God loves us so much that He personally paid the cost in our place in the person of Jesus Christ (John 3:16). This is an illustration of God declaring the end from the beginning (Isaiah 46:10). Yeah, He did know we were going to sin and He also had a plan already put in place to reconcile us to Him. Instead of accusing God of being unfair, we should be more grateful that He’s actually not. Why should God be punished for what we’re guilty of? Where is the fairness in that?
All we’re left with in the end is a truth claim made by a skeptic, who can’t do that without borrowing from God to begin with. Remind these people that they’re not standing on their own ground when they take this stance. They claim a reality based on chance over time, a reality in which you can’t really say you know anything for certain, yet they make truth claims because they know that God holds all things together (the induction principle).
Why does truth matter in a world of meaninglessness? Why is it important that people be honest when debating about anything at all? The world is not meaningless and the truth is important because God has declared it to be so. The truth claim at the end makes this meme self refuting.